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KMID : 1007520220310010101
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Food Science and Biotechnology
2022 Volume.31 No. 1 p.101 ~ p.110
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Immune-modulation effect of Halocynthia aurantium tunic lipid on RAW264.7 cells
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Jang A-Yeong
Monmai Chaiwat
Rod-in Weerawan
Kim Ji-Eun
You Sang-Guan
Lee Tae-Ho
Park Woo-Jung
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Abstract
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The current study evaluated the immune-regulatory potential of lipid extract from Halocynthia aurantium tunic on macrophage cells. The results showed that H. aurantium lipid is composed of primarily SFA (68.32%), followed by MUFA and PUFA (17.61% and 14.07%, respectively). Halocynthia aurantium lipid dose-dependently modulated the NO and PGE2 production in RAW264.7 cells without any LPS stimulation. The lipid effectively up-regulated the cytokine expression, including IL-1β, IL-6, and TNF-α in RAW264.7 cells. The COX-2 expression as a key biomarker for inflammation was also significantly increased. Conversely, H. aurantium lipid down-regulated the expression of inflammatory cytokines in LPS-stimulated RAW264.7 cells. Halocynthia aurantium lipid modulated the phosphorylation of NF-κB p-65, p38, ERK, and JNK, indicating that this lipid activated through NF-κB and MAPK pathways. These results provide insight into the immune-regulatory activities of H. aurantium tunic lipid and suggest that H. aurantium tunic may a potential lipid source for immune-regulatory molecules.
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KEYWORD
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Halocynthia aurantium, Lipid, Immune-regulation, NF-κB, MAPK
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